Clinics in Dermatology
Volume 24, Issue 2 , Pages 109-112, March 2006

Herpes gestationis (Pemphigoid gestationis)

  • Abdul-Wahab S. Al-Fouzan, MD

      Affiliations

    • Department of Dermatology, Al-Sabah Hospital, PO Box 1161, Safat-13002, Kuwait
    • Corresponding Author InformationCorresponding author. Department of Dermatology, Al-Sabah Hospital, PO Box 1161, Safat-13002, Kuwait. Tel.: +965 2666120; fax: +965 2666121.
    • ,
  • Ibrahim Galadari, MD

      Affiliations

    • Dermatology Department, United Arab Emirates University, Dubai, UAE
    • ,
  • Isam Oumeish, MD

      Affiliations

    • Department of Dermatology, King Hussein Medical Center, 11831 Amman, Jordan
    • ,
  • Oumeish Y. Oumeish, MD

      Affiliations

    • Department of Dermatology, Tulane University School of Medicine, New Orleans, LA 70112-2632, USA

Abstract 

Herpes gestationis, coined by Milton in 1872, or gestational pemphigoid is the most clearly characterized dermatosis of pregnancy. It is a rare vesiculo-bullous eruption that develops during the last trimester or even postpartum and creates severe pruritus. Its etiology is unknown, but it is considered as an autoimmune-mediated dermatosis closely related to the pemphigoid group. Herpes gestationis is associated with a positive C3 deposition along the base of the epidermis in salt–split skin, with increased frequency of HLA-DR3 and also the combination DR3 and DR4. It has a high risk of prematurity and disappears in the postpartum period within weeks or months.

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PII: S0738-081X(05)00129-X

doi:10.1016/j.clindermatol.2005.10.011

Clinics in Dermatology
Volume 24, Issue 2 , Pages 109-112, March 2006

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